We are a clinical-stage company, pioneering radically new antibody therapeutics for oncology.
We have unique and proprietary expertise in the discovery and development of IgE, IgA and IgG-based therapeutics with each isotype possessing differentiated immune effector function.
Evolved to treat parasitic infection, IgE has significant activity against various tumour types by activating myeloid cells and T cells thereby warming up the tumour micro-environment. IgA’s anti-cancer potential is mediated by the activation of neutrophils. The distinct activity profiles of each isotype allow us to select the most appropriate isotype for a given cancer.
Our lead clinical candidate, MOv18 IgE, targets folate receptor alpha (FRα). It has successfully completed a phase I trial in ovarian cancer and was found to be safe and well tolerated with early signs of clinical activity. A phase Ib trial of MOv18 IgE in platinum-resistant ovarian cancer (PROC) is underway.
Epsilogen has created a number of platforms based on its expertise with the IgE, IgA and IgG isotypes including bispecific IgE and IgEG antibodies.
Management Team
Tim Wilson, PhD.
Chief Executive Officer
Kevin FitzGerald
Chief Scientific Officer
Cristina Oliva
Chief Medical Officer
Nick Robbins-Cherry
Chief Financial Officer
Elizabeth Hardaker
Chief Translational Science Officer
Leanne Partington
VP of Product Development
Andrew Calam
VP of Clinical Operations
Board of Directors
Tim Wilson, PhD.
Chief Executive Officer
Pete Finan
Non-Executive Chairman
Marianne Uteng
Board Member
Marianne Bjørdal
Board Member
Alek Safarian
Board Member
Emma Johnson
Board Member
Sonia Gulati
Board Member
Advisers
Robert Coleman
Clinical Advisor
Susana Banerjee
Clinical Advisor
Thomas Herzog
Clinical Advisor