Harnessing the power of IgE in Oncology

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Why IgE?

IgE evolved to kill multicellular tissue-dwelling parasites. Epsilogen is harnessing this power to kill solid tumours

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MOv18 IgE

MOv18 IgE targets ovarian cancer and is the first therapeutic IgE antibody to enter clinical trials.

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IgEGs

Epsilogen has used its IgE expertise to build a fusion antibody combining the best of IgE and IgG

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Laboratory Equipment in Epsilogen laboratory

Epsilogen is a global leader in the development of immunoglobulin E (IgE) antibodies to treat cancer. IgE has several key features that make it ideal for the treatment of solid tumours including greater potency, enhanced tumour access and a long tissue half-life.

The company’s lead product candidate, MOv18 IgE, has successfully completed a phase I clinical trial in folate receptor alpha positive cancer patients. This is the world’s first IgE drug to enter clinical trials. MOv18 IgE was found to be safe and well tolerated with early signs of clinical activity seen.
https://www.nature.com/articles/s41467-023-39679-9

Epsilogen has constructed a novel and proprietary pipeline of anti-cancer IgE and IgE-derivative antibodies with enhanced functionality.

Recent Press Releases

Epsilogen and Lonza Announce Successful Large-Scale GMP Manufacturing of MOv18, an IgE Antibody Targeting Ovarian Cancer

March 5, 2024

First time GMP manufacturing of a therapeutic IgE antibody has been achieved at scale GMP ...

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Epsilogen announces successful completion of first ever clinical trial of an IgE antibody; phase I data for MOv18 IgE demonstrates potential of IgE therapy in cancer

July 25, 2023

Final results of phase I study of MOv18 IgE in ovarian cancer published in Nature ...

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Epsilogen announces significant expansion of management team with three new senior hires

April 26, 2023

Appointments allow company to consolidate its position as a global leader in the discovery and ...

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